Biden’s nominee for Interior responded to GOP bluster with grace and is headed for confirmation.

PLAYISM, the digital indie games storefront that launched in 2011 with a focus on Japanese releases, has announced that they will be terminating sales of games and content on March 24th, 2021. R…

A "Terminator" anime series has been ordered at Netflix, Variety has learned.

In-car touchscreens are problem enough for average, well-rested drivers. For millions of Americans like me, they're outright dangerous.

Nevada is proposing legislation that would allow major technology companies to effectively form independent techno-governments. 

Christian Bale & Director Scott Cooper Re-Team On 'The Pale Blue Eye' For Cross Creek: EFM

Researchers discovered humans' oldest primate ancestors in Montana fossils that date back over 65 million years.

More than a dozen of former President Donald Trump's closest Republican allies in the House have skipped Friday's votes and enlisted their colleagues to vote on their behalf, signing letters saying they can't attend "due to the ongoing public health emergency."

All previous DLC from 2nd Encore is now free for all Skullgirls players!

Star Michael C. Hall shared Dexter revival details for Showtime's limited series revival from original showrunner Clyde Phillips.

The fees are part of increased legal expenses of $27.5 million primarily related to regulatory/legal matters in connection to fraud claims by a short seller.

The WNBA and NBA approved the sale of the Atlanta Dream, officials said Friday, ending the contentious ownership of former U.S. Sen. Kelly Loeffler.

General Motors' Buick brand has a higher percentage of female buyers in the United States than any other automotive brand, according to a recent study.

CoinMarketCal is the leading economic calendar for reliable cryptocurrency news. It covers all events that help crypto traders make better decisions.

LISBON — Portugal last year recorded its steepest economic contraction since 1936 as both domestic and external demand weakened due to the COVID-19 pandemic,…

The U.S. Air Force’s chief of staff wants the service to develop an affordable, lightweight fighter to replace hundreds of aging F-16s and complement a small fleet of sophisticated F-35 stealth fighters. But an affordable, lightweight fighter is exactly what the F-35 was first conceived to be.

DiCaprio met with Osage cultural leaders to help him better prepare for his role as Ernest Burkhart in Scorsese's upcoming Western drama.

There are no non-hormonal male contraceptives currently on the market despite decades of efforts toward the development of “male pills”. Here, we report that triptonide, a natural compound purified from the Chinese herb Tripterygium Wilfordii Hook F displays reversible male contraceptive effects in both mice and monkeys. ... Single daily oral doses of triptonide induces deformed sperm with minimal or no forward motility (close to 100% penetrance) and consequently male infertility in 3–4 and 5–6 weeks in mice and cynomolgus monkeys, respectively. Male fertility is regained in ~4–6 weeks after cessation of triptonide intake in both species. Either short- or long-term triptonide treatment causes no discernable systematic toxic side effects based on histological examination of vital organs in mice and hematological and serum biochemical analyses in monkeys. Triptonide appears to target junction plakoglobin and disrupts its interactions with SPEM1 during spermiogenesis. Our data further prove that targeting late spermiogenesis represents an effective strategy for developing non-hormonal male contraceptives. No male contraceptive pills are currently available. Here, the authors use triptonide, a compound derived from a Chinese plant, to deform sperm so that they cannot move properly, thereby causing reversible infertility in male mice and monkeys.
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